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陈发杰
日期:2023-02-27 阅读次数: 作者: 来源:

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姓 名:陈发杰

别:男

称:副教授/硕士生导师

历:博士

务:

话:18868818089

业:有机化学

电子邮件:fajie.chen@fzu.edu.cn

研究方向:有机合成方法学,多肽化学


教育与工作经历

2023.02至今      新葡萄平台网站-官方App Store - Apple App Store,副教授

2020.11-2022.11           波士顿学院 (Boston College),美国, 博士后,导师: Jianmin Gao教授

2018.11-2020.11           伊利诺伊大学芝加哥分校 (University of Illinois at Chicago), 美国,博士后,导师: Daesung Lee教授

2016.10-2018.11           中国科学院福建物质结构研究所,博士后,苏伟平 教授

2011.9-2016.9               浙江大学化学系,博士,导师:史炳锋 教授,吴军教授

2007.9-2011.6               福州大学化学化工学院,本科,导师:陈义平 教授,史炳锋 教授


教学简介


科研简介

主要从事有机合成方法学、多肽化学等研究,已Angew. Chem. Int. Ed. Chem. Sci.Org. Lett.Org. Chem. Front.等国际刊物上发表SCI论文14篇,其中2篇论文入选ESI高被引论文,1篇热点论文,论文总被引用1000余次。研究成果先后多次被 ChemInform, Synfacts, Chin. J. Org. Chem.等作为亮点进行报道。主持国家自然科学基金1项,参与国家自然科学基金1项。

科研领域主要涉及:

1. 复杂环肽的合成

2. 天然多肽的特异性修饰与转化

3. 惰性化学键的活化与转化

社会兼职


科研项目

4. 天然多肽的特异性修饰与拓扑结构调控研究(511264),福州大学旗山学者海外项目,2023-2027,在研,主持

3. 过渡金属催化的饱和羰基化合物的脱氢/双官能团化串联反应研究(21702205),国家自然科学基金青年项目, 2018-2020,已结题,主持

2. β-取代色氨酸合成方法及其在MaremycinsTMC-95A的合成应用研究(21402170,国家自然科学基金青年项目, 2015-2017,已结题,参与

1. 新型糖肽类抗生素Mannopeptimycins的仿生合成及多样化合成(21272206,国家自然科学基金面上项目,2013-2016,已结题,参与


代表性论文



14. Chen, Fa-Jie;# Pinnette, Nicole;# Yang, Fan; Gao, Jianmin.* "A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization" Angew. Chem. Int. Ed. 2023, e202306813.


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13. Chen, Fa-Jie; Gao, Jianmin.* "Fast Cysteine Bioconjugation Chemistry" Chem. Eur. J. 2022, e202201843. (Invited Review)


2AC6E

12. Zheng, Mengmeng; Chen, Fa-Jie, Li, Kaicheng; Reja, Rahi M.; Haeffner, Fredrik; Gao, Jianmin* "Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display" J. Am. Chem. Soc. 2022, 144, 15885-15893.


C9E2

11. Chen, Fa-Jie;# Zheng, Mengmeng,# Nobile, Vincent, Gao, Jianmin.* "Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes" Chem. Eur. J. 2022, e202200058. (Hot paper)


1331C

10. Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkatareddy; Liu, Huaqing; Lee, Daesung* Xia, Yuanzhi*. "Three-component Coupling Reaction for the Synthesis of Fully Substituted Triazoles: Reactivity Control of Cu-Acetylide toward Alkyl Azides and Diazo Compounds" Org. Chem. Front., 2021, 8, 6095.


B63D

9. Chen, Fa-Jie; Hua, Zhenguo; Chen, Jianhui; Chen, Jiajia; Lee, Daesung* and Xia, Yuanzhi*. "One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation" Front. Chem. 2020, 8, 621545.

BD3B

8. Chen, Fa-Jie; Lin, Yongjia; Xu, Man; Xia, Yuanzhi*; Wink, Donald J.; Lee, Daesung*. "C–H Insertion by Alkylidene Carbenes to Form 1,2,3-Triazines and Anionic [3 + 2] Dipolar Cycloadditions To Form Tetrazoles: Crucial Roles of Stereoelectronic and Steric Effects" Org. Lett. 2020, 22, 2, 718-723.

1BFD8

7. Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping.* "Copper-catalyzed Dehydrogenative γ-C(sp3)-H Amination of Saturated Ketones for Synthesis of Polysubstituted Anilines" Nat. Comm. 2019, 10, 3681.


B880

6. Zhao, Sheng; Chen, Fa-Jie; Liu, Bin; Shi, Bing-Feng.* "Copper-Catalyzed Direct Acyloxylation of C(sp2)-H Bonds with Benzoic Acids" SCIENCE CHINA Chemistry, 2015, 58, 1302-1309.


606F

5. Zhao, Sheng; Liu, Yue-Jin; Yan, Sheng-Yi; Chen, Fa-Jie; Zhang, Zhuo-Zhuo; Shi, Bing-Feng.* "Copper-/Silver-Mediated Arylation of C(sp2)–H Bonds with 2-Thiophenecarboxylic Acids." Org. Lett. 2015, 17, 3338-3341.


3689

4. Chen, Fa-Jie; Liao, Gang; Li, Xin; Wu, Jun*; Shi, Bing-Feng* "Copper-Mediated CS/NS Bond Formation via CH Activation: Access to Benzoisothiazolones Using Elemental Sulfur" Org. Lett. 2014, 6, 5644-5647.

435F

3. Li, Xin; Liu, Yan-Hua; Gu, Wen-Jia; Li, Bo; Chen, Fa-Jie; Shi, Bing-Feng.* "Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary" Org. Lett. 2014, 16, 3904-3907.


E1AC

2. Zhang, Qi; Chen, Kai; Rao, Wei-Hao.; Zhang, Yuejun; Chen, Fa-Jie, Shi, Bing-Feng.* "Stereoselective Synthesis of Chiral α-Amino-β-Lactams via Pd(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)–H Bonds" Angew. Chem. Int. Ed. 2013, 52, 13588-13592. (高被引论文)


5203

1. Chen, Fa-Jie; Zhao, Sheng; Hu, Fang; Chen, Kai; Zhang, Qi; Zhang, Shuo-Qing; Shi, Bing-Feng.* "Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers" Chem. Sci. 2013, 4, 4187-4192. (Top 25 most-read Chemical Science articles in 2013) (高被引论文)


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获奖情况

2023年入选福州大学旗山学者(海外项目)

2018年入选中国科学院福建物质结构研究所精英博士后

2015年入选浙江大学优秀研究生


其他






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